FOXO4-DRI
Prodigy Peptides

FOXO4-DRI

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Comprehensive Research Overview: FOXO4-DRI

FOXO4-DRI (D-Retro-Inverso isoform peptide) is a cutting-edge senolytic agent engineered to selectively eliminate damaged, non-dividing "senescent" cells. By clearing these "zombie cells," researchers aim to mitigate the pro-inflammatory environment they create, potentially reversing tissue decline and age-related pathologies.

 

Mechanism of Action: Targeted Apoptosis

The primary function of FOXO4-DRI is its ability to act as a competitive antagonist against the FOXO4-p53 interaction.

  • Disrupting Senescent Survival: In aged cells, the FOXO4 protein binds to the p53 tumor suppressor, sequestering it and preventing it from triggering cell death.

  • Inducing Programmed Cell Death: FOXO4-DRI disrupts this bond, releasing p53 to the mitochondria where it initiates apoptosis (programmed cell death) exclusively in damaged cells.

  • Selectivity: This mechanism is highly specific; it leaves healthy, functional cells relatively untouched, which promotes the rejuvenation of the surrounding tissue.


Key Research Fields & Therapeutic Potential

1. Systemic Aging and Organ Vitality

In breakthrough murine studies, FOXO4-DRI has demonstrated the ability to reverse signs of aging and restore organ function.

  • Kidney & Liver Health: Treatment showed significant improvements in renal and hepatic markers in aged mouse models.

  • Physical Appearance: Research subjects exhibited increased fur density and improved overall physical fitness.

2. Reproductive Health (Hypogonadism)

Studies published in Aging-US highlight that FOXO4-DRI may alleviate testosterone secretion insufficiency.

  • By targeting senescent Leydig cells, the peptide improves the testicular microenvironment and boosts natural hormonal production in aged subjects.

3. Autoimmune Support & Kidney Lupus

FOXO4-DRI is being investigated for its role in treating Systemic Lupus Erythematosus (SLE).

  • Research highlights indicate that the peptide induces apoptosis in senescent cells within lupus-affected kidney tissues, significantly improving overall renal function.

4. Oncology and Chemotoxicity

Researchers have utilized FOXO4-DRI to combat the side effects of chemotherapy.

  • In mouse models, it has been shown to reduce the systemic toxicity caused by potent drugs like doxorubicin, potentially allowing for more effective cancer treatment protocols.

5. Joint and Tissue Repair

 

Note: This information is for research purposes only. FOXO4-DRI is currently intended for laboratory use to further explore its potential in senolytic therapy.

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity


Our RUO peptides are engineered via precision synthesis, utilizing meticulously validated protocols to ensure uncompromising accuracy and batch-to-batch consistency. To maintain verified purity, every production lot undergoes independent third-party analysis—including HPLC and mass spectrometry—to confirm molecular identity and a purity of >98%. For expedited research timelines, we provide same-day fulfillment from our U.S. facility, ensuring rapid and reliable delivery of all orders.

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