KISSPEPTIN
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KISSPEPTIN-10
Research-Grade Neuropeptide & HPG Axis Regulator
Product Overview
Kisspeptin-10 is a potent, truncated 10-amino acid peptide derived from the human KISS1 gene product. As the most biologically active fragment of the larger Kisspeptin-54 hormone, it serves as the primary endogenous ligand for the KISS1 receptor (GPR54). In preclinical research, Kisspeptin-10 is utilized to study the Hypothalamic-Pituitary-Gonadal (HPG) axis, where it acts as the "master switch" for the initiation and regulation of reproductive function.
Key Research Applications
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HPG Axis Orchestration: Studied for its role at the apex of the reproductive axis, where it stimulates the pulsatile secretion of GnRH from the hypothalamus.
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Gonadotropin Release: Investigated for its ability to indirectly trigger the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).
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Metastasis Suppression: Originally identified as "metastin," it remains a key subject in studies exploring the suppression of melanoma and breast cancer metastasis.
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Reproductive Behavior: Evaluated for its influence on extra-hypothalamic regions of the brain that mediate sexual attraction, mood, and emotional processing.
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Metabolic Integration: Used to study how nutritional status and leptin signaling interact with the reproductive system to regulate fertility.
Why Researchers Choose Kisspeptin-10
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Receptor Potency: Maintains maximal biological activity at the KISS1 receptor level with a high binding affinity (Ki ~2.33 nM).
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Specific Signaling: Induces rapid intracellular calcium release and PKC activation through the Phospholipase C (PLC) pathway.
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Short Duration of Action: Features a short circulating half-life (~4 minutes), making it ideal for acute pulse-response studies.
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Batch Verified: Identity and potency are confirmed via HPLC and Mass Spectrometry for consistent research results.
Technical Specifications
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Sequence: YNWNSFGLRF-NH2
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Molecular Weight: ~1302.45 Da
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Molecular Formula: C_{63}H_{83}N_{17}O_{14}
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Formulation: Lyophilized powder for maximum shelf-life and experimental stability.
Research Notice: Kisspeptin-10 is strictly for laboratory and scientific research use only. Not for human or animal consumption, veterinary use, or diagnostic purposes.