KISSPEPTIN
KISSPEPTIN

KISSPEPTIN

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KISSPEPTIN-10

Research-Grade Neuropeptide & HPG Axis Regulator

Product Overview

Kisspeptin-10 is a potent, truncated 10-amino acid peptide derived from the human KISS1 gene product. As the most biologically active fragment of the larger Kisspeptin-54 hormone, it serves as the primary endogenous ligand for the KISS1 receptor (GPR54). In preclinical research, Kisspeptin-10 is utilized to study the Hypothalamic-Pituitary-Gonadal (HPG) axis, where it acts as the "master switch" for the initiation and regulation of reproductive function.

Key Research Applications

  • HPG Axis Orchestration: Studied for its role at the apex of the reproductive axis, where it stimulates the pulsatile secretion of GnRH from the hypothalamus.

  • Gonadotropin Release: Investigated for its ability to indirectly trigger the release of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH).

  • Metastasis Suppression: Originally identified as "metastin," it remains a key subject in studies exploring the suppression of melanoma and breast cancer metastasis.

  • Reproductive Behavior: Evaluated for its influence on extra-hypothalamic regions of the brain that mediate sexual attraction, mood, and emotional processing.

  • Metabolic Integration: Used to study how nutritional status and leptin signaling interact with the reproductive system to regulate fertility.

Why Researchers Choose Kisspeptin-10

  • Receptor Potency: Maintains maximal biological activity at the KISS1 receptor level with a high binding affinity (Ki ~2.33 nM).

  • Specific Signaling: Induces rapid intracellular calcium release and PKC activation through the Phospholipase C (PLC) pathway.

  • Short Duration of Action: Features a short circulating half-life (~4 minutes), making it ideal for acute pulse-response studies.

  • Batch Verified: Identity and potency are confirmed via HPLC and Mass Spectrometry for consistent research results.

Technical Specifications

Research Notice: Kisspeptin-10 is strictly for laboratory and scientific research use only. Not for human or animal consumption, veterinary use, or diagnostic purposes.

Validated Synthesis & Expedited Fulfillment

Clinical-Grade Synthesis & Purity


Our RUO peptides are engineered via precision synthesis, utilizing meticulously validated protocols to ensure uncompromising accuracy and batch-to-batch consistency. To maintain verified purity, every production lot undergoes independent third-party analysis—including HPLC and mass spectrometry—to confirm molecular identity and a purity of >98%. For expedited research timelines, we provide same-day fulfillment from our U.S. facility, ensuring rapid and reliable delivery of all orders.

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