IGF-1 LR3
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IGF-1 LR3 (Insulin-like Growth Factor-1 Long R3)
Advanced Anabolic & Regenerative Research Compound
Product Overview
IGF-1 LR3 is a synthetic, 83-amino acid analogue of human insulin-like growth factor-1 (IGF-1). It is modified with an arginine substitution at position 3 and a 13-amino-acid N-terminal extension, which prevents it from binding to IGF-binding proteins (IGFBPs). This results in a significantly extended half-life of 20–30 hours and increased biological potency compared to native IGF-1. Researchers utilize IGF-1 LR3 to investigate muscle hypertrophy, cellular proliferation, and metabolic energy dynamics.
Key Research Applications
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Muscle Hypertrophy & Repair: Widely studied for its ability to stimulate satellite cell activation and enhance protein synthesis in skeletal muscle models.
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Regenerative Science: Evaluated in research regarding the repair of tendons, ligaments, and connective tissues.
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Metabolic Regulation: Investigated for its influence on glucose uptake and amino acid transport within various cellular models.
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Cellular Proliferation: Serves as a primary tool for exploring signaling cascades like the PI3K-AKT and MAPK pathways associated with cell growth and survival.
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Neurotrophic Studies: Evaluated for its potential to support neuronal survival and synaptic plasticity through its interaction with the IGF-1 receptor.
Why Researchers Choose IGF-1 LR3
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Superior Potency: Approximately three times more potent than native IGF-1 due to reduced binding with inhibitory proteins.
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Extended Half-Life: Features a prolonged elimination half-life of 20–30 hours, allowing for sustained biological activity in experimental settings.
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High Analytical Purity: Verified to be ≥95% pure (typically via SDS-PAGE and HPLC) to ensure consistent and reproducible research data.
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Experimental Versatility: Suitable for a broad range of applications, from stem cell culture maintenance to musculoskeletal and neural studies.
Technical Specifications
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Molecular Weight: Approximately 9.1 kDa.
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Formulation: Supplied as a lyophilized powder for maximum stability.
Research Notice: IGF-1 LR3 is strictly for laboratory and scientific research use only. Not for human or animal consumption, medical treatment, or therapeutic use.
